Table 2.
Evaluation between early abstinence and outcomesa
| Duration of early abstinence | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 Week | 2 Weeks | 3 Weeks | 4 Weeks | |||||
| IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | |
| Missing = missingb | ||||||||
| Drinks per drinking day | 3.40 | 2.63–4.39 | 3.43 | 2.67–4.41 | 3.60 | 2.79–4.65 | 4.69 | 3.60–6.10 |
| Number of drinking days | 3.56 | 2.86–4.44 | 3.77 | 3.03–4.67 | 4.08 | 3.28–5.07 | 5.15 | 4.13–6.43 |
| Number of heavy drinking days | 3.81 | 2.92–4.97 | 3.77 | 2.89–4.91 | 3.87 | 2.96–5.04 | 5.27 | 4.01–6.94 |
| Missing = imputedb , c | ||||||||
| Drinks per drinking day | 3.02 | 2.36–3.88 | 3.13 | 2.45–3.99 | 3.33 | 2.60–4.27 | 4.2 | 3.25–5.43 |
| Number of drinking days | 3.29 | 2.65–4.07 | 3.60 | 2.92–4.43 | 3.94 | 3.19–4.87 | 4.87 | 3.93–6.04 |
| Number of heavy drinking days | 3.40 | 2.63–4.39 | 3.42 | 2.65–4.40 | 3.63 | 2.81–4.69 | 4.87 | 3.74–6.35 |
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Time to first drinking dayd | 5.78 | 4.84–6.94 | 6.09 | 5.06–7.33 | 5.80 | 4.80–7.01 | 6.05 | 4.94–7.41 |
| Time to first heavy drinking dayd | 4.97 | 4.13–5.99 | 4.88 | 4.02–5.93 | 4.78 | 3.90–5.85 | 5.19 | 4.16–6.47 |
aAll analyses included interactions between time and treatment assignment, and adjusted for site, sex, age, percent medication adherence, being assigned to receive acamprosate, naltrexone, CBI, pretreatment drinking and heavy drinking days and scores on the URICA Readiness Scale. Variables are comparing Early Abstainer and Early Nonabstainer groups. All comparisons are statistically significant at the P < 0.001 level; referrant group = Early Abstainer during period of interest; IRR = incidence-rate ratio; HR = hazard ratio; CI = confidence interval.
bPoisson regression models.
cMultiple imputation for missing data.
dCox proportional hazard model.