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. 2016 Nov 15;27(23):3687–3694. doi: 10.1091/mbc.E16-05-0273

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© 2016 Ehrentraut, Curtis, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — The combination of proinflammatory cytokines with the neddylation inhibitor MLN4924 leads to increased barrier disruption. (A) TER of T84 cells on Transwell inserts during a 24-h time course with control, cytomix (10 ng/μl each of TNF-α, IL-1β, and IFN-γ), 1 μM MLN4924, or cytomix plus MLN4924 (n = 3). (B) FITC-flux assay of T84 cells on Transwell inserts after a 24-h time course with control, cytomix, 1 μM MLN4924, or cytomix plus MLN4924 (n = 3). (C) Luciferase assay detecting activation of caspase-3/7 of T84 cells treated with control, cytomix, 1 μM MLN4924, or cytomix plus MLN4924 for 24 h, *p < 0.05.