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. 2016 Nov 15;27(23):3687–3694. doi: 10.1091/mbc.E16-05-0273

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© 2016 Ehrentraut, Curtis, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Neddylation inhibition increases disease severity in a TNBS model of colitis. (A) Treatment of C57/BL6 mice treated with 2.5% TNBS and MLN4924 s.c. at 3 mg/kg per day shows decreased survival in mice receiving TNBS plus MLN4924 (29 total mice). (B) Decreased colon length in mice receiving TNBS plus MLN4924 compared with TNBS alone. (C) Histological colonic sections of mice treated with or without TNBS and with or without MLN4924. (D) TUNEL staining in mouse colon sections from TNBS plus MLN4924 experiment. (E) Cleaved caspase 3 IF staining in mouse colon sections from TNBS plus MLN4924 experiment. (F) Analysis of tissue injury index in mice receiving a combination of TNBS plus MLN4924 in comparison to TNBS alone. (G) Increased IL-1 and IL-6 protein expression as detected by MesoScale in mice receiving TNBS plus MLN4924 compared with TNBS alone.