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. 2016 Nov 15;27(23):3687–3694. doi: 10.1091/mbc.E16-05-0273

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© 2016 Ehrentraut, Curtis, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — Decreased expression of SENP8 in colitis model and in IBD patients. (A) mRNA expression of SENP8 is decreased in T84 cells after treatment with cytomix (10 ng/μl each of TNF-α, IL-1β, and IFN-γ) for 24 h (n = 3). (B) mRNA expression of SENP8 is decreased in a TNBS model of colitis on days 1 and 3 after treatment (14 total mice). (C) Expression of SENP8 in colon tissue is decreased in patients with active Crohn’s disease and ulcerative colitis compared with nonactive healthy controls, *p < 0.05, ***p < 0.01.