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. 2016 Nov 15;27(23):3695–3704. doi: 10.1091/mbc.E16-04-0253

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© 2016 Chia et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Dose-dependent effects of LatB and CytoD on neurite outgrowth and accumulation of F-actin at neurite tips. (A, B) Rat hippocampal neurons cultured for 3 DIV in normal medium (untreated) or treated with DMSO or indicated concentrations of LatB (LB) or CytoD (CD) during the last 24 h. Fixed cells were stained with phalloidin (cyan) or Tuj1 antibody (red). Arrows point to F-actin accumulations. Scale bars, 50 μm (A), 10 μm (B). (C–E) Concentration dependence of the average percentage of F-actin–positive neurite tips (C; 98–407 neurites), average length of the longest neurite (D; 96–338 neurites), and average number of neurites per cell (E; 172–472 neurites) in neuron cultures treated with LatB (blue) or CytoD (red). Median ± SEM. Statistical significance (*p < 0.01; **p < 0.001) determined relative to DMSO treatment.