FIGURE 1:

Schematic representation of known phosphorylation sites in human TTP family members. (A) NTD and CTD represent the N-terminal and C-terminal activation domains on either sides of the zinc-finger (ZF) RNA-binding domain (RBD). The serines that have been shown previously to regulate TTP family function upon phosphorylation are indicated in red. Corresponding serines in mouse proteins are indicated with brackets. The conserved C-terminal sequence between TIS11b and TIS11d is indicated between dotted lines. Other phosphoserines have been identified in vitro and in phosphoproteomic studies of ectopically expressed TTP (reviewed in Venigalla and Turner, 2012). However, the relevance of these phosphosites remains to be validated experimentally. No phosphorylated serines in TIS11d/BRF2 have been reported so far. (B) Protein kinases regulating TTP family fate and function. aa, amino acid.