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. 2016 Nov 1;27(21):3245–3256. doi: 10.1091/mbc.E16-05-0287

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© 2016 Rao et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — ER distribution during regeneration in spastin mutant neurons. ER accumulation patterns in class I ddaE neurons during injury-induced axon regeneration. White arrows indicate the ddaE cell body. (A) An injured neuron that failed to regrow and has Rtnl1-GFP accumulation in multiple neurites (red arrows), (B) an injured neuron with <75 μm of regrowth and Rtnl1-GFP accumulation in a single neurite (orange arrow), (C) an injured neuron with >75 μm of regrowth and Rtnl1-GFP accumulation in the regrowing neurite (green arrow; green dashed lines trace the new axon. White dotted lines show a dendrite from a neighboring neuron), and (D) an injured neuron with multiple neurites regrowing, each with Rtnl1-GFP accumulation in the tips (blue arrows). (E) Quantification of regeneration in control (yw) and spas^5.75/10-12 neurons. Long and short horizontal bars indicate mean and SD respectively, and an unpaired t test was used to calculate significance. (F) Percentage of neurons with ER accumulation in single or multiple neurite tips in control and spas^5.75/10-12 neurons. (G) Percentage of neurons with different categories of growth and ER accumulation patterns. Colors correspond to arrows in A–D.