FIGURE 2:

Syntaxin-1 expression strongly reduces calcium currents in SNAP-25 KO cells. (A) Viral overexpression of syntaxin-1A or the LE mutant of syntaxin-1A led to a strong decrease in calcium current amplitudes. Means ± SEM. ***p < 0.001 (one-way ANOVA, Tukey’s post hoc test). N = 3, n = 17–19. (B) The I/V relationship was depressed but not shifted upon syntaxin overexpression. (C) The activation window was not affected by syntaxin overexpression. (D) The inactivation curve was slightly shifted toward more positive potentials upon syntaxin-1A overexpression.