Appendix 1.

Summary Table of Articles Reviewed

#	Author/Title/ Ref	Study Type	Context & Population Studied	Aims of Initiative being reported on	Methods/ Tools used	Results/Outputs	Critical Appraisal Quality of Methods and Tools Relevance to research questions
1	National Health Service. (2015)	Review	Worldwide	Provides overview of new developments in biomedical devices	Systematic Review of Literature	Provides a succinct overview of new biomedical device development	High quality systematic review
	Biotechnology; New Findings in Biomedical Informatics [34]						Relevant because it discusses the disruptive nature of some new biomedical devices and the effect on clinical work processes of their implementation.
2	Atun R. (2015).Tronsitioning health systems for multimorbidity [1]	Review	Worldwide	To increase understanding of the impact of chronic disease	Summary of the 2013 WHO Report on the Impact of chronic disease	Discusses the impact on health systems in both developing and developed countries of chronic diseases	Succinct commentary in Lancet
							Relevant because it summarises the impact of chronic diseases on the health system
3	Bakshi A, et al. (2013) Adaptive policy framework: A systematic review [7]	Review	Australia	Used to provide a robust methodology	Systematic Review of Literature	Robust methodology	Robust methodology
4	Costelnuovo G, etol. (2015) New Technologies for the Management and Rehabilitation of Chronic Diseases and Conditions. [4]	Article	Worldwide	Provide an overview of new technologies	Survey new biomedical technologies	Potential for the development of a new and innovative model of healthcare as represented by such technologies as telemedicine, e-heolth applications, biomedical sensors and devices, integrated platforms and technologies for remote monitoring and management, web and Internet based clinical protocols, and m-heolth solutions.	Summary article
							Relevant in that it gave a concise summary of new technologies for the management of chronic diseases
5	Chen Z, et al. (2015) Dissecting an Online Intervention for Cancer Survivors. [27]	Article	USA	To understand how cancer survivors use social media to support self-management	Qualitative methods-semi structured interviews and analysis of text from posts	Four Exploratory Analyses of Internet Engagement and Its Effects on Health Status and Health Behaviors.”	Rigourous analysis of cancer survivor posts on social media.
							Relevant in that it showed how cancer survivors can receive emotional and social support using social media
6	Conway A, et al. (2014) Effective Technologies for Noninvasive Remote Monitoring in Heart Failure. [12]	Article	UK	Explanation of self monitoring technology for heart patients	A sub analysis of a large systematic review and meta-analysis was conducted. Studies were stratified according to the specific type of technology used, and separate meta-analyses were performed.	This sub analysis identified that only two of the four specific technologies used for noninvasive remote monitoring in heart failure improved outcomes.	Rigourous analysis
							Relevant in that it provived recent examples of self managed bio-meicol technologies and critiqued their effectiveness
7	EI-Goyor O, etol. (2013) Onthe Design of IT-Enobled Self-Care Systems: A Socio-technical Perspective. [24]	Article	USA	Discussion of user acceptance issues of IT enabled health care systems	Analysis of design issues	Identified key socio-technical principles for IT enabled self care systems	In-depth review of sociotechnicol issues associated with design and use of IT enabled self care systems
							Relevant in that it presented a set of sociotechnicol based principles for system design and effectiveness
8	El-Gayar OF, et al. (2010) Evaluating task-technology fit and user performance for an electronic health record system. [26]	Article	USA	Discussion of task technology fit for an EHR	Analysis of design issues	Identified key design principles to enable health IT systems to align with clinical processes	Identifies eight dimensions for measuring and evaluating health information system performance.
							Strong methodology used to obtain perceptions of task-technology fit by surveying 100 nurses.
9	Emery J. (2014) Cancer survivorship - the role of the GP. [3]	Review	Aust. Cancer Survivors-GPs	Improve chronic disease mgmt. in Primary Care	Literature review of Australian trials of shared and GP based care management	Pts need quick route back to oncologist if needed, Integrated EHR needed Holistic care of GP is valuable e.g. co-morbidities	Comprehensive review of existing trials - need for more research
		GP Role					Very highly relevant to research question - GP information needs, information system characteristics.
10	Erfani SS, e† al. (2014) Effects of Web based cancer support resources use on cancer affected people: A systematic literature review. [29]	Review	Australia and world wide	Understanding the impact of web based support resources use on cancer affected people	Science Direct, Springer Link, IEEE Explore, Google Scholar, and expert consultation to select articles, thirty five (35) of which met the selection criteria.	Results showed the use of web based support recourses by cancer affected people enabled them to archive health and psychological related benefits.	Comprehensive review of existing resources - need for more research
							Very highly relevant to research question- EHealth & Management of Chronic diseases
11	Forczek E, et al. (2015) The Internet as a New Tool in the Rehabilitation Process of Patients-Education in Focus. [9]	Article	Hungary	Understanding the rehabilitation of patients using information technology, especially Internet support	Examination of experience in Hungarian health system	In the development of rehabilitation programmes, the knowledge of the IT professional and the therapist, in the IT support of web guidance, medical expertise plays the primary role.	Limited in scope and coverage. Hungary seems well behind in e Health development
							Relevant in that examined tHe IT specialist/clinician communication issues needing to be addressed to develop effective IT support for rehab programs
12	Harris, M. (2012) Patients with Colorectal cancer: A qualitative study of referral pathways and continuing care. [30]	Article	Australia	Understanding Referral Pathways	Qualitative Interviews with Clinicians	Relationships are paramount in determining referral pathways	Rigorous
							Relevant in that it is important eHealth systems to take into account clinician relationships
13	Jameson JL (2015) Precision Medicine - Personalized, Problematic, and Promising. [13]	Article	USA	Understanding trends in Precision Medicine	Review	Precision Medicine will enable personalized treatment and will be a disruptive force	Very comprehensive overview of precision medicine.
							Relevant in that it is a major trend that eHealth will need to deal with
14	Jonsen F, et al. (2015) Cancer survivors’ perceived need for supportive care and their attitude towards self- management and eHealth. [23]	Study	Cancer Survivors in Germany	To explore the perceived need for supportive care including healthy lifestyle programs among cancer survivors, their attitude towards self-management and eHealth	A questionnaire on the perceived need for supportive care and attitude towards self-management and eHealth was completed by 212 cancer survivors from an online panel.	The perceived need for supportive care includ- ing healthy lifestyle programs was high, and in general, cancer survivors had a positive attitude towards self-management and eHealth.	Highly relevant in that the article examines Cancer survivors’ perceived need for supportive care and their attitude towards self-management and eHealth.”
15	Kerr C, et al. (2005). Interactive health communication applications for chronic disease: patient and carer perspectives. [31]	Study	UK Cancer survivors	Analysis of patient acceptance of INTERACTIVE eHealth applications	Qualitative – 4 focus groups	Showed broad acceptance of eHealth applications – with Web 2.0 interactivity – emphasis on good HC interaction	Limited in scope but highly relevant and generalizable.
							Relevant for patient acceptance.
16	Khan NF, et al. (2011) A qualitative study of unmet needs and interactions with primary care among cancer survivors. [20]	Qual. Research	UK Cancer Survivors in 2 NE England Counties N=40	To explore the experiences of individuals who have survived at least 5 years following a cancer diagnosis, and to describe perceived unmet needs and interactions with primary care.	Grounded Theory Approach — semi-structured interviews - coded themoticolly using NVivo 7 qualitative analysis software (Doncaster, Australia) by one researcher (NK).	Cancer survivors cited three main reasons for not using GP services in relation to their cancer diagnosis. GPs were seen as non-experts in cancer; they were perceived as too busy; and a lack of continuity within primary care made it difficult to talk about long-term issues.	Rigorous qualitative study.
		Patient Perspective					Relevant in that it described areas of GP capability that were perceived as lacking — specialised cancer knowledge and lack of integrated, continuity of care.
17	Khatun F, et al. (2015). Determinants of readiness to adopt mHealth in a rural community of Bangladesh. [17]	Study	To understand factors required for the take-up of eHealth in developing countries	Survey	A conceptual framework for mHeolth readiness was developed, which included three categories: technological, motivational and resource readiness. This guided the questionnaire development for the survey conducted in the Chokorio sub-district of Bangladesh	A total of 4915 randomly selected household members aged 18 years and over completed the survey. The data explained the sub-categories of the readiness dimensions. In terms of access, 45% of respondents owned a mobile phone with ownership higher among males, younger participants and those in the highest socioeconomic quintiles. Results related to technological readiness showed that among mobile phone owners, 50% were aware of SMS but only sending and receiving SMS.	Very rigorous methodology
							Highly relevant in that it detailed the conditions need to enable take-up of eHealth in developing countries
18	Li J, et al. (2014). Health Care Provider Adoption of eHealth: Systematic Literature Review. [10]	Review	To identify and synthesize influential factors to health care providers’acceptance of various eHealth systems.	Identified factors were analyzed and grouped in accordance with the Unified Theory of Acceptance and Use of Technology (UTAUT).	Systematic Literature Review	There would be potential to extend theories on information technology adoption, which is of great benefit to readers interested in learning more on the topic. Practically, these findings may help health care decision makers proactively introduce interventions to encourage acceptance of eHealth and may also assist health policy makers refine relevant policies to promote the eHealth innovation.	Comprehensive literature review highly relevant to research question
19	Liaw ST, et al. (2013). Towards an ontology for data quality in integrated chronic disease management: A realist review of the literature. [8]	Review	To improve understanding of an ontological approach to DQ as a potential solution and address existing research in this area which is limited and fragmented.	Screened 245 papers, excluded 26 duplicates, 135 on abstract review and 31 on full-text review; leaving 61 papers for critical appraisal. Of the 33 papers that examined ontologies in chronic disease management, 13 defined data quality and 15 used ontologies for DQ.	Systematic Literature Review	Most saw DQ as a multidimensional construct, the most used dimensions being completeness, accuracy, correctness, consistency and timeliness.	Focused on data quality Effective use of routine data to support integrated chronic disease management (CDM) and population health is dependent on underlying data quality (DQ) and, for cross system use of data, semantic interoperability.
							Highly relevant because of its rigorous and re-usable methodology
20	Deborah K. Mayer (22/06/2015)	Quality Research	USA-Colon Cancer Survivors	Implementing Survivorship Care Plans for Colon Cancer Survivors	Study to evaluate the feasibility, usability, and satisfaction of a survivorship care plan (SCP) and idenifify the optimum time for its delivery during the first 12 months after diagnosis.	The Survivor Care Plans were well received by the survivors and their PCPs, but were too time and labor intensive to track and complete. Electronic Health Records may improve efficiency. Need for other process issues to be addressed e.g. patient selection	Rigorous study from a nursing perspective. Well-described methodology. Small size study (n = 49). Very highly relevant to research question – PCP information needs, information system characteristics. Patient feedback
	Implementing Survivorship Core Plans for Colon Cancer Survivors	GP & Nursing Role
21	McAvoy BR (2007). General practitioners and cancer control. [18]	Personal Experience	Australian GPs and Cancer Survivors	Aims to describe the role of GPs in managing cancer survivors	Aims to describe the role of GPs in managing cancer survivors	GPs cover the full spectrum of cancer care from prevention to palliation, including providing psychosocial support to patients and their families and carers. GPs have a key role in early diagnosis and referral, follow-up and detection of recurrence, and survivorship. There is a developing role for GPs in cancer policy and research.	Older study but issues still relevant
							P- GPs and Cancer survivors in Australia
							1 - GPs have a key role in early detection, managing side effects of treatment and follow up monitoring and survivorship
							C-Not relevant
							O - GPs are in the best position to provide coordinated and continuity of care especially in dealing with co morbidities, which two thirds of cancer patients have.
22	Meier CA, et al (2013). eHealth: Extending, Enhancing, and Evolving Health Care. [11]	Review	Focus on worldwide uptake of eHealth solutions — majority of examples from USA	Wide-ranging review of past, present and predicted future of eHeolth. Examines eHealth definition, benefits and adoption challenges	Systematic Review of Literature	Predicts eHealth will have an increasingly vital role in improving the efficiency of the health system.	Comprehensive, well referenced review of literature but somewhat high level. A good overview but it kept to a high level.
23	Lorenzo Moja (04/07/2015) Effectiveness of Computerized Decision Support Systems Linked to Electronic Health Records: A Systematic Review and Meta-Analysis	Lit Review	Sixteen RCTs contributed to this analysis.--A total of 37 395 individuals participated in these trials: 18 848 in the intervention groups and 18 547 in the control groups.	Conducted a systematic review to rigorously evaluate the impact of CDSSs linked to EHRs on critical outcomes-mortality, morbidity, and costs	Searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Cochrane Database of Abstracts of Reviews of Effects. Information on system design, capabilities, acquisition, implementation context, and effects on mortality, morbidity, and economic outcomes were extracted.	This systematic review of 28 RCTs revealed little evidence for a difference in mortality when pooling results from comparisons of adoption of a CDSS integrated with an EHR versus health care settings without a CDS. We found weak evidence that an active CDSS is associated with a lower risk for morbidity.	Extensive literature search. Rigorous analysis of the literature. Study did not consider the following outcomes: patient satisfaction, measures of process, and health care professional activity or performance (e.g., adherence to guidelines, rates of screening and other preventive measures, provision of counseling, rates of appropriate drug administration, and identification of at-risk behaviors).
						The beneficial effects of CDSSs might still be greater than that suggested by the current analysis given the limited number of actual studies providing results on hard outcomes.	Relevant to the research question – study casts doubt on the effectiveness of CDSSs to reduce mortality.
24	Roorda C, et al. Discharge of breast cancer patients to primary care at the end of hospital follow-up: A cross-sectional survey. Europ J Cancer 2013;49(8):1836-44.	Survey of GPs	Dutch GPs N=527	Discharge of breast cancer patients to primary care at the end of hospital follow-up: A cross-sectional survey	Survey to 976 GPs resulting in a 53% return rate. Then regression analysis of results	Perceived barriers in current and future primary care-based follow-up included: communication with breastcancer specialists, patients’ preference for specialist follow-up, GPs’ oncology knowledge and skills and the organisation of follow-up in general practice.	Large sample size enabled sophisticated statistical analysis. Survey had limitations - inconsistent response rate, self- reporting, cross- sectional (not longitudinal)
							Relevant in that it highlighted attitudes of GPs and patients towards GP follow up. GPs need a threshold number of patients to be able to build up their expertise.
							Survivorship care plans are needed to facilitate communication across the primary/secondary interface and with patients. Training of GPs and developing administrative tools may be helpful in arranging follow-up care and using guidelines in general practice.
25	Rulond CM, et al. (2013). Evaluation of differentfeotures of an eHeolth application for personalized illness management support: Cancer patients’ use and appraisal of usefulness. [25]	Study	Norway Cancer Survivors	To describe patients’ use of a multi-component eHeolth application, WebChoice, designed to support cancer patients in illness management.	Analyzed user logs of breast and prostate cancer patients who participated in the experimental arm of an RCT to test effects of WebChoice on clinical outcomes. Patients could freely use the system for one year.	The Forum and asking questions to the nurse were used the most, yet there were large individual variations in use patterns. Also, patients used different WebChoice components for different reasons. The e-mail communication with nurses was valued highest.	Rigorous
							Relevant because it was one of few studies which looked at how cancer survivors actually used an eHeolth support system. It highlighted the functions and features most valued by patients
26	Vos T et al. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. [2]	Review	Worldwide	To quantify the impact of chronic diseases on health systems in both developed and developing countries	Analyzed statistics provided from WHO member countries	The worldwide burden of non-communicable diseases is expected to increase from 46% in 2001 to 57% in 2020	Classic study on worldwide burden of chronic diseases. Rigorous methodology. Useful background material on how rapidly increasing burden of chronic diseases will challenge health systems to become more efficient.
27	Zulmon D, et al. (2015). How Can eHeolth Technology Address Challenges Related to Multimorbidity? [33]	Review	USA	To understand how eHeolth systems should be designed to address multiple chronic conditions	Qualitative study giving perspectives from Patients with Multiple Chronic Conditions	Patients suffering chronic diseases need to have access to eHeolth applications, which consolidate and synthesize information about multiple co-morbidities, such as applications that help identify potential medication-medication or condition-medication interactions	Rigorous
							Makes the point that many people with chronic diseases have multimorbidities, which need to be addressed holisticolly, and e Health systems need to support this.
28	Mendoza G, et al. (October 2014). mHeolth Compendium, Volume Four. [5]	Review	USA	To give an overview of recent developments in mHealth in sub-Sohoron Africa	Meta analysis of published studies	There are many successful mHeolth projects mostly funded by USAID that are enabling greater access to health care	Comprehensive overview of mHeolth projects up to 2014
29	Balabanova D, et al. (2013). Good health at low cost 25 years on: lessons for the future of health system strengthening. [15]	Review	UK	To give an overview of recent developments in developing countries	Meta analysis of published studies	Discusses progress made in eHeolth and lessons learned	Rigorous review