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. 2016 Dec 20;6:39630. doi: 10.1038/srep39630

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) PRKAR1A was differently expressed in adenocarcinoma and normal tissue (P < 0.001). (B) The comparison of PRKAR1A expression from 102 adenocarcinoma patients’ cancerous lung tissues with the respective adjacent normal tissues. (C) Kaplan-Meier survival curves for the two groups of lung adenocarcinoma patients. The overall survival times in the low (blue, n = 70) and high PRKAR1A (red, n = 32) groups, with a hazard ratio of 1.91 (95% confidence interval (CI) 1.09–3.34) and P = 0.0233. Statistical significance was assessed by paired t-test (A) and Mantel-Cox log-rank test (C). (D) The decreased level of PRKAR1A protein was detected in 61 out of 102 tumor samples compared with the paired normal tissues (N, normal tissue; A, adenocarcinoma). The representative Western blot images of PRKAR1A was illustrated and normalized against GAPDH.