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. 2016 Dec 20;6:39630. doi: 10.1038/srep39630

Figure 3. Aberrant PRKAR1A expression influenced adenocarcinoma cells’ tumorigenesis in the lung.

Figure 3

(A–D) A549 or H1299 cells were infected with silenced (shPRKAR1A) or encoded PRKAR1A virus and compared with an empty retrovirus (shCtrl or vector). Cells were injected into the tail vein of nude mice. (A) Schematic of the in vivo tumorigenesis assay in the lung. (B and C) Number of metastasis of each nude mice. (D) Representative images of the gross lung [D, upper], and H&E stained lung sections, with arrows pointing to tumors. n = 5 for each group, data were mean ± SD.