Table 3.
Phenotype of Canine Immune Subsets
| Cell | Positive CD Markers | Negative CD Markers |
|---|---|---|
| Helper T cell | CD4,a CD45 | CD21 |
| Cytotoxic T cell | CD8, CD45, IFN-γ | CD21 |
| Activated Memory T cell | CD25, CD44, CD45, CD69 | CD62L |
| Regulatory T cell | CD4, CD25, CD45, FoxP3 | CD8 |
| B cell | CD22, CD79a, CD45, CD25, MHC2 | TCR |
| Dendritic cell | CD11c, MHC II, CD80, CD14 | N/A |
| Macrophage | MHC II, Mac-3/Lamp2/107b, F4/80, CD11b, CD206 | N/A |
| Natural Killer cell | CD5 dim, CD45, MHC1, MHC2, NKp46 | CD5 (after 14 days in culture), CD4, CD21 |
aPossibly unique to canines, CD4 is expressed in granulocytes. Similar to other species, CD4 is expressed in a subset of monocyte-derived cells