Table 1.

List of ALK mutations known to be oncogenic

Alteration	Location	Functional significance	Tumor type	Reference(s)
H694R	Extracellular	Increased phosphorylation, promotes tumors in mice		Wang et al. 2011
K1062M	Juxtamembrane	Transforms cells, promotes tumors in mice	Neuroblastoma	Chen et al. 2008; Murugan and Xing 2011
G1128A	Kinase domain, glycine-rich region	Increased phosphorylation	Neuroblastoma	Mosse et al. 2008; Bossi et al. 2010; Schonherr et al. 2011
M1166R	Kinase domain	Increased phosphorylation	Neuroblastoma	Mosse et al. 2008; Chand et al. 2013
F1174I	Kinase domain	Increased phosphorylation	Neuroblastoma	Chand et al. 2013; Mologni et al. 2015
F1174L	Kinase domain	Disrupts auto-inhibitory function	Neuroblastoma	Chen et al. 2008; George et al. 2008; De Brouwer et al. 2010; Sasaki et al. 2010; Bresler et al. 2011; Heuckmann et al. 2011; Kodama et al. 2014; Infarinato et al. 2015; Zou et al. 2015
F1174S	Kinase domain	Ligand-independent activity	Neuroblastoma	Martinsson et al. 2011
L1198F	Kinase domain	Increased phosphorylation	Thyroid	Murugan and Xing 2011
G1201E	Kinase domain	Increased phosphorylation	Thyroid, Skin	Murugan and Xing 2011
F1245C	Kinase domain	Increased phosphorylation	Neuroblastoma	Schonherr et al. 2011; Infarinato et al. 2015
R1275Q	Kinase domain	Disrupts auto-inhibitory function	Neuroblastoma	Chen et al. 2008; George et al. 2008; De Brouwer et al. 2010; Bagci et al. 2012; Carpenter and Mosse 2012
E1384K	Kinase domain	Increased phosphorylation	Cervix	Wang et al. 2011