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. 2016 Dec 20;6:38644. doi: 10.1038/srep38644

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) MEDI1912 and MEDI1912_STT PK profiles following intravenous administration of a 3 mg/kg dose to rats (n = 3). (b) Human bladder, cerebellum and kidney tissue immunohistochemically stained with MEDI1912 and MEDI1912_STT at 0.18 μg/mL. Significant staining was demonstrated by MEDI1912, showing strong staining in connective tissue, smooth muscle (around blood vessels) and other areas that is consistent with non-specific staining. MEDI1912_STT showed no evidence of staining in any tissues evaluated. (c) MEDI1912_STT retains functional potency in vitro compared with MEDI1912 in a phospho-ERK activation assay. Data points represent the mean ± SD.