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. 2016 Dec 16;7:13819. doi: 10.1038/ncomms13819

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Copyright © 2016, The Author(s)

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(a,b) Side view parallel to the membrane plane of superimposed five-TM repeat 1 (TM1+TM3–6) in the T and O state (yellow and red, respectively). (a) TM2 moves upward towards the periplasm by ∼2.5 Å in the transition from T to O. (b) The upward movement of TM2 relocates bound fusidic acid towards the periplasmic side of the membrane (surface representation, yellow: position in the T conformation, red: position in the O conformation). (c) Localization of the membrane/periplasmic space interface based on the position of the alkyl chains and hydrophilic maltose moieties of the DDM molecules co-crystallized with AcrB (dashed line). (d) Localization of fusidic acid molecule in complex with AcrB in the T conformer. (e) Localization of fusidic acid molecule in complex with AcrB in the O conformer. (f) Superimposition of the T and O conformers including the fusidic acid and DDM molecules.