Table 1. Differential metabolites in response to Asian ginseng treatment.
| No. | RT (min) | Compound | Formula | VIP valuea | p valueb | FCc | Trend |
|---|---|---|---|---|---|---|---|
| 1 | 21.70 | Glycerol 1-palmitate* | C19H38O4 | 1.646 | 1.11E-04 | 0.631 | Down |
| 2 | 6.42 | Tartaric acid | C4H6O6 | 1.607 | 5.03E-06 | 4.130 | Up |
| 3 | 11.49 | Pyroglutamic acid* | C5H7NO3 | 1.604 | 3.33E-05 | 2.945 | Up |
| 4 | 18.78 | Stearic acid* | C18H36O2 | 1.537 | 1.34E-04 | 4.558 | Up |
| 5 | 17.76 | Uric acid* | C5H4N4O3 | 1.475 | 3.86E-04 | 40.648 | Up |
| 6 | 5.15 | L-Lactic acid* | C3H6O3 | 1.471 | 6.66E-06 | 0.352 | Down |
| 7 | 14.10 | Aconitic acid* | C6H6O6 | 1.370 | 9.18E-05 | 2.499 | Up |
| 8 | 8.24 | Glycerol | C3H8O3 | 1.336 | 2.37E-03 | 2.815 | Up |
| 9 | 13.70 | 5-Hydroxyindole | C8H7NO | 1.305 | 1.72E-05 | 2.672 | Up |
| 10 | 21.03 | Ribothymidine* | C10H14N2O6 | 1.285 | 1.56E-03 | 2.426 | Up |
| 11 | 14.01 | Putrescine* | C4H12N2 | 1.256 | 1.37E-05 | 10.298 | Up |
| 12 | 17.70 | Myo-Inositol* | C6H12O6 | 1.221 | 1.61E-04 | 2.433 | Up |
| 13 | 11.43 | Erythritol* | C4H10O4 | 1.221 | 1.47E-02 | 0.684 | Down |
| 14 | 8.69 | Glycine* | C2H5NO2 | 1.191 | 2.75E-04 | 29.617 | Up |
| 15 | 15.19 | D-Pinitol | C7H14O6 | 1.166 | 1.00E-03 | 4.144 | Up |
| 16 | 8.71 | Succinic acid | C4H6O4 | 1.141 | 7.47E-03 | 4.862 | Up |
| 17 | 12.80 | 4-Hydroxyphenylacetic acid* | C8H8O3 | 1.113 | 2.37E-03 | 1.608 | Up |
| 18 | 17.00 | Palmitic acid* | C16H32O2 | 1.047 | 1.82E-02 | 1.973 | Up |
| 19 | 12.65 | L-Glutamic acid* | C5H9NO4 | 1.047 | 3.86E-04 | 20.301 | Up |
| 20 | 14.961 | Citric acid* | C6H8O7 | 1.031 | 5.19E-03 | 3.083 | Up |
| 21 | 16.54 | Gluconic acid | C6H12O7 | 1.015 | 8.40E-03 | 1.855 | Up |
aVariable importance in the projection (VIP) was obtained from OPLS-DA with a threshold of 1.0.
bp value was calculated from Wilcoxon-Mann U test.
cFold change (FC) was calculated from the arithmetic mean values between ASG and CON group. The metabolites marked with “*” were structurally identified by reference standards.