Table 3. Relation of log-formed serum markers of angiogenesis with brachial ankle pulse wave velocity (baPWV) and measures of cardiac structure and function in CKD stages 3–5 subjects.
| Angpt2 | Angpt1 | Angpt2/Angpt1 | VEGF | |
|---|---|---|---|---|
| baPWV, per 100 cm/s Unstandardized β(95% Cl) | ||||
| Age and sex adjusted | 1.07(−1.64,3.78) | −0.49(−2.14,1.15) | 0.64(−0.67,1.94) | 0.46(−2.96,3.88) |
| Multivariable adjusted | 0.07(−2.03,2.17) | 0.46(−1.58,2.49) | 1.31(−0.67,3.28) | 0.31(−3.76,4.36) |
| Log LVMI Unstandardized β(95% Cl) | ||||
| Age and sex adjusted | 0.09(0.02,0.17)a | −0.04(−0.09,0.01) | 0.05(0.01,0.09)a | −0.06(−0.14,0.02) |
| Multivariable adjusted | 0.09(0.01,0.16)a | −0.02(−0.08,0.03) | 0.05(0.00,0.09)a | −0.05(−0.14,0.04) |
| LAD, per 1 cm Unstandardized β(95% Cl) | ||||
| Age and sex adjusted | 0.19(−0.18,0.57) | −0.30(−0.56, −0.04)a | 0.23(0.02,0.44)a | −0.33(−0.75,0.08) |
| Multivariable adjusted | 0.05(−0.36,0.45) | −0.30(−0.58, −0.02)a | 0.18(−0.06,0.41) | −0.23(−0.67,0.21) |
| LVFS, per 1% Unstandardized β(95% Cl) | ||||
| Age and sex adjusted | −1.96(−6.42,2.51) | −0.28(−3.42,2.86) | −0.57(−3.11,1.96) | 1.68(−3.28,6.65) |
| Multivariable adjusted | −1.01(−5.81,3.79) | −1.00(−4.48,2.47) | −0.11(−3.02,2.80) | 0.52(−4.82,5.85) |
| E/A < 1 OR(95% CI) | ||||
| Age and sex adjusted | 1.21(0.17,8.83) | 0.38(0.10,1.52) | 2.53(0.83,7.72) | 5.34(0.51,56.30) |
| Multivariable adjusted | 1.64(0.14,19.35) | 0.41(0.07,2.32) | 3.26(0.70,15.20) | 7.77(0.49,123.13) |
Abbreviations: LAD, left atrial diameter; LVFS, left ventricular fraction shortening; E/A, peak early transmitral filling wave velocity/peak late transmitral filling wave velocity; Angiopoietin-2, Angpt2; Angiopoietin-1, Angpt1; VEGF, vascular endothelial growth factor; OR, odds ratio.
Multivariable model: adjusted for age, sex, diabetes mellitus, heart disease, cigarette smoking, estimated glomerular filtration rate, serum hemoglobin and cholesterol levels.
aP-value < 0.05.