Table 1. Correlation between different measures of disease comorbidity.
| Criteria for disease pairs | XD |
NG |
||
|---|---|---|---|---|
| RR | PHI | RR | PHI | |
| +XDand+NG | 0.2640 (6.59 × 10−4) | 0.1377 (2.687 × 10−3) | −0.0065 (0.3789) | 0.0251 (0.1329) |
| +XD | 0.2592 (5.20 × 10−4) | 0.1432 (2.29 × 10−3) | −0.0047 (0.2466) | 0.0344 (0.0474) |
| +NG | 0.2407 (3.26 × 10−4) | 0.1267 (1.184 × 10−3) | −0.0023 (0.1753) | 0.0360 (0.0338) |
| +NGnot+XD | 0.0059 (0.0764) | −0.0209 (0.9999) | 0.0096 (0.0892) | 0.0288 (0.0357) |
| +XDnot+NG | 0.0886 (0.0132) | 0.0723 (0.0305) | NA | NA |
| not+XDnot+NG | −0.0029 (0.8218) | 0.0040 (0.1130) | NA | NA |
| ALL | 0.1557 (6.67 × 10−6) | 0.0759 (0) | 0.0013 (0.0521) | 0.0254 (0.0016) |
Numbers represent Pearson’s correlation coefficients for XD scores against RR/PHI scores or for NG values against RR/PHI scores calculated from different sets of disease pairs constructed by different categories shown at the first column; p-values in parenthesis are from permutation tests.
+XD: disease pairs having positive XD scores.
+NG: disease pairs having at least one common gene.
+XDand +NG: disease pairs having both positive XD score and at least one common gene.
+NGnot+XD: disease pairs having at least one common gene but without having positive XD scores.
+XDnot+NG: disease pairs having positive XD scores but without having common disease genes.
not+XDnot+NG: disease pairs having negative XD scores and without having common disease genes.