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. 2016 Dec 19;6:39453. doi: 10.1038/srep39453

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Copyright © 2016, The Author(s)

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(a) Differential scanning calorimetry (DSC) traces of Ub-FKBP12 (upper) and Ub₆-FKBP12 (lower). Black traces show initial heating of Ub-FKBP12 to 330 K (upper) and Ub₆-FKBP12 to 332 K (lower); red lines show respective reheating of the same samples. Peak assignments were based on previous DSC measurements of FKBP12 and (poly-)ubiquitin⁷. (b) ¹H-¹⁵N HMQC spectra of non-heated (blue) and heated (335 K) (red) ubiquitylated FKBP12. Upper, 40 μM Ub-FKBP12 at 298 K; lower, 48 μM Ub₆-FKBP12 at 310 K. Most of the peaks observed for folded FKBP12 were not detected in the spectrum of heat-treated ubiquitylated FKBP12; however, (poly-)ubiquitin remained folded after heat treatment.