Density distribution of SNVs (B), INDELs (C), mapped onto the gene map of the HSR 1 isolate, coinciding with the “profile” (A). Central region of the genome is rather conserved (lower density of SNVs is exhibited in the second third of the genome, ORF 1b), while the rest of the genome features high SNVs density. SNV peaks are present at (absolute HSR 1) positions 3,852, 9,404, 9,479, 11,493, 17,564 (ORF lab), 21,721, 22,222 (S protein), 26,477 (M protein), and 27,827 (ORF 8a).