Table 3.
Mutation Analysis of the S Protein: Categories of Nucleotide Substitutions
| 1.pos | 2.pos | 3.pos | Total No. | 1.pos% | 2.pos% | 3.pos% | Total% | Silent | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transitions | A-G | A→G | 6/15 | 2/8 | 3/20 | 11/43 | 16/73 | 7.21% | 3.85% | 9.62% | 20.68% | 3/20 |
| G→A | 2/7 | 2/22 | 1/1 | 5/30 | 3.37% | 10.58% | 0.48% | 14.43% | 1/1 | |||
| C-T | C→T | 3/7 | 6/25 | 6/19 | 15/51 | 24/94 |
3.37% | 12.02% | 9.13% | 24.52% | 6/19 | |
| T→C |
2/3 |
3/29 |
4/11 |
9/43 |
1.44% |
13.94% |
5.29% |
20.67% |
4/11 |
|||
| Total | 13/32 | 13/84 | 14/51 | 40/167 | 15.38% | 40.38% | 24.52% | 80.28% | 14/51 | |||
| Transversions | A→C | A→C | 2/2 | 1/1 | 2/2 | 5/5 | 8/10 | 0.96% | 0.48% | 0.96% | 2.40% | 2/2 |
| C→A | 1/1 | 1/2 | 1/2 | 3/5 | 0.48% | 0.96% | 0.96% | 2.40% | 0 | |||
| A-T | A→T | 0 | 0 | 0 | 0 | 6/7 | 0 | 0 | 0 | 0 | 0 | |
| T→A | 2/2 | 1/1 | 3/4 | 6/7 | 0.96% | 0.48% | 1.92% | 3.37% | 1/1 | |||
| G-C | G→C | 1/1 | 0 | 0 | 1/1 | 3/5 | 0.48% | 0 | 0 | 0.48% | 0 | |
| C→G | 0 | 2/4 | 0 | 2/4 | 0 | 1.92% | 0 | 1.92% | 0 | |||
| G-T | G→T | 0 | 1/1 | 1/1 | 2/2 | 5/19 |
0 | 0.48% | 0.48% | 0.96% | 1/1 | |
| T→G |
2/14 |
0 |
1/3 |
3/17 |
6.73% |
0 |
1.44% |
8.17% |
1/3 |
|||
| Total | 8/20 | 6/9 | 8/12 | 22/41 | 9.62% | 4.33% | 5.77% | 19.72% | 5/7 | |||
| Total | 21/52 | 19/93 | 22/63 | 62/208 | 25.00% | 44.71% | 30.29% | 100% | 19/58 | |||
S proteins in 91 isolates are considered. The number of transition and transversion sites and the number of SNVs (in the form N1/N2) per position in codon and per mutation type, as well as the percentage of SNVs, and the number of silent mutation sites and silent SNVs (in the form N1/N2), are presented.