Table 2. Main toxicokinetic parameters (mean ± SD) of DON after single IV (n = 10) and PO (n = 6) bolus administration of 0.3 mg/kg BW to racing pigeons.
| IV | PO | |
|---|---|---|
| AUC0-90 (ng*h/mL) | 27.0 ± 8.4 | 8.2 ± 4.5 |
| Cmax (ng/mL) | - | 10.1 ± 5.2 |
| C0 (ng/mL) | 94.9 ± 45.4 | - |
| Tmax (h) | - | 0.5 ± 0.2 |
| kel (/h) | 2.3 ± 0.7 | 1.2 ± 0.4 |
| t1/2el (h) | 0.3 ± 0.1 | 0.6 ± 0.2 |
| Vd a(L/kg) | 5.7 ± 18 | 28.1 ± 15.2 |
| Cl b (L/h*kg) | 12.5 ± 4.8 | 31.8 ± 15.2 |
| F(%) | 100 | 30.4 |
AUC0-90, area under the curve from time 0 to 90 minutes post administration; Cmax, maximum plasma concentration; C0, plasma concentration at time = 0; Tmax, time of maximum plasma concentration; kel, elimination rate constant; t1/2el, half-life of elimination; Vd, volume of distribution; Cl, clearance; F, absolute oral bioavailability. The Vd (a) and Cl (b) of DON following PO administration were corrected for the absolute oral bioavailability.