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. 2016 Dec 20;11(12):e0168189. doi: 10.1371/journal.pone.0168189

Table 5. Sensitivity and specificity of AFP according to concomitant albumin levels and NA therapy.

Group 1 2 3 4
NA (-) Albumin ≥ 3.7 NA (+) Albumin ≥ 3.7 NA (-) Albumin < 3.7 NA (+) Albumin < 3.7
Number (HCC-associated) 20,702 (105) 29,330 (234) 685 (37) 2,420 (73)
Youden index 0.646 0.497 0.369 0.215
Cutoff (ng/mL) 3.9 5.3 25.0 67.2
Sensitivity 80 65 49 33
Specificity 85 85 87 89