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Schematic view of Dia-induced DCs maturation. When encountered with immature DCs, Dia could induce DCs maturation by up-regulating the expression of MHCII and other co-stimulatory molecules via CD36 and NF-κB signals. As the same time, the expression of CCR7 was also up-regulated, resulting in a high migration ability towards MLN. After arriving at MLN, DCs promoted Th1 polarization.
