Table 1. Results of CD8, FOXP3, PD-1 and PD-L1 immunohistochemistry.
| Immune marker | CD8 n (%) | FOXP3 n (%) | PD-1 n (%) | PD-L1 n (%) |
|---|---|---|---|---|
| Dichotomized total score* | <6 vs ≥6 | <4 vs ≥4 | <3 vs ≥3 | <3 vs ≥3 |
| Low total score | 85 (58.6) | 38 (26.2) | 79 (54.5) | 104 (71.7) |
| High total score | 60 (41.4) | 107 (73.8) | 66 (45.5) | 41 (28.3) |
| Dichotomized intraepithelial compartment score* | ≤2 vs >2 | 1 vs 2 | 1 vs 2 | 1 vs ≥2 |
| Low total score | 72 (49.7) | 39 (26.9) | 130 (89.7) | 118 (81.4) |
| High total score | 73 (50.3) | 106 (73.1) | 15 (10.3) | 27 (18.6) |
| Dichotomized tumor stroma compartment score* | ≤2 vs >2 | ≤2 vs >2 | 1 vs ≥2 | 1 vs ≥2 |
| Low total score | 115 (79.3) | 38 (26.2) | 93 (64.1) | 116 (80) |
| High total score | 30(20.7) | 107 (73.8) | 52 (35.9) | 29 (20) |
| Dichotomized tumor periphery compartment score* | 1 vs ≥2 | 1 vs 2 | 1 vs 2 | 1 vs ≥2 |
| Low total score | 60 (59.4) | 37 (25.5) | 105 (72.4) | 118 (81.4) |
| High total score | 41(40.6) | 108 (74.5) | 40 (27.6) | 27 (18.6) |
*
Dichotomized labelling (low vs high score) based on the median value of immune marker expression. Total score accounted for all three compartment scores (intraepithelial, stroma, periphery).