Table 4. Prognostic impact of the immune markers in the different tumor compartments.

TILs marker and tumour compartment	OS p-value	PFS p-value	LPFS p-value	DMFS p-value
CD8
Tumor periphery	0.086	0.087	0.175	0.092
Tumor stroma	0.021	0.034	0.068	0.004
Tumor intraepithelial	0.632	0.320	0.142	0.567
FOXP3
Tumor periphery	0.342	0.456	0.489	0.390
Tumor stroma	0.569	0.839	0.664	0.756
Tumor intraepithelial	0.721	0.541	0.289	0.367
PD-1
Tumor periphery	0.253	0.048	0.121	0.025
Tumor stroma	0.022	0.028	0.013	0.008
Tumor intraepithelial	0.117	0.027	0.071	0.020
PD-L1
Tumor periphery	0.162	0.305	0.286	0.479
Tumor stroma	0.259	0.307	0.259	0.475
Tumor intraepithelial	0.162	0.345	0.268	0.352

Abbreviations: OS, overall survival; progression-free survival; PFS, progression-free survival; LPFS, local progression-free survival; DMFS, distant metastases-free survival;

Significant values have been marked with bold.