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. 2016 May 17;7(27):41067–41080. doi: 10.18632/oncotarget.9392

Figure 5. YLL545 inhibits tumor cell growth in vitro.

Figure 5

A. Cell viability assays were conducted using MDA-MB-231 cells treated with different concentrations of YLL545. At the indicated time points, cell growth inhibition was determined. **P < 0.01 vs respective control in a one-way ANOVA followed by Tukey's HSD test. B. Colony formation assays were conducted using MDA-MB-231 cells treated with different concentrations of YLL545 for 7 days. **P < 0.01 and ***P < 0.001 vs respective control in Student's t-test. C. EdU proliferation assays were conducted using MDA-MB-231 cells treated with different concentrations of YLL545 for 72 h. ***P < 0.001 vs respective control in Student's t-test. Scale bars, 50 μm. D. MDA-MB-231 cells were treated with different concentrations of YLL545 for 72 h, and annexin V/PI staining was analyzed using flow cytometry. The proportions of early apoptotic cells (annexin V-positive) and late apoptotic cells (PI-positive) are shown. **P < 0.01 vs respective control in Student's t-test.