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. 2016 May 10;7(27):41154–41171. doi: 10.18632/oncotarget.9273

Table 1. Melanoma Prognostic Signature.

Prognostic Signature Number of Genes/Gene Group Total Number P Value Reference
Upregulated A7 vs Control
Up regulated genes in neural crest development of melanocytes, differentiation and pigmentation and down regulated genes in angiogenesis, neurogenesis, immunomodulation and interaction and remodeling extracellular environment 39/65 0 Jeffs et al., 2009
Genes downregulated in aggressive melanoma cells 24/60 0 Ryu et al., 2007
Genes with low expression in metastatic melanomas vs melanocytes 8/23 0 Riker et al., 2008
Genes with low expression in primary cutaneous melanomas vs melanocytes 12/21 0 Riker et al., 2008
Genes downregulated in metastatic vs primary melanomas 6/38 0,036 Jaeger et al., 2007
Downregulated in A7 vs Control
Genes upregulated in positive metastatic melanoma 69/183 0 Winnepenninckx et al., 2006
Genes upregulated in vertical vs radial growth melanomas 26/48 0 Ryu et al., 2007
Genes downregulated in melanomas with low proliferative and high metastatic capacity 4/5 0,002 Hoek et al., 2006
Genes upregulated in melanomas with low proliferative and high metastatic capacity 4/5 0,004 Hoek et al., 2006
Upregulated in G10 vs Control
Prolonged survival 9/50 0 Bogunovic et al., 2009
Genes upregulated in MGP melanoma cells vs melanocytes 10/29 0 Pfaff Smith et al., 2005
Down regulated genes in neural crest, melanocyte development, differentiation and pigmentation and up regulated genes in angiogenesis, neurogenesis, immunomodulation and interaction and remodeling of extracellular environment 12/31 0,008 Jeffs et al.,2009
Genes upregulated in melanomas with low proliferative and high metastatic capacity 3/5 0,008 Hoek et al., 2006
Genes downregulated in melanomas with low proliferative capacity and high metastatic capacity 2/5 0,008 Hoek et al., 2006
Genes upregulated in vertical vs radial growth melanomas 13/48 0,012 Ryu et al.,2007
Downregulated in G10 vs Control
Genes downregulated in metastatic melanomas vs primary melanomas 4/17 0 Jaeger et al., 2007
Molecular signature of metastatic melanomas 3/11 0,016 Wang et al., 2012