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. 2016 May 9;7(27):41217–41232. doi: 10.18632/oncotarget.9251

Figure 2. The increase in the CSCs in marrow is not an acute phase response and not due to selection.

Figure 2

The CSCs in prostate cancer recovered from bone marrow ((A) PC3 and (B) C4-2B), mRNA expression in prostate cancer cells ((C) PC3 and (D) C4- 2B), and secretion of inflammatory cytokines in marrow ((E) PC3 and (F) C4-2B) analyzed over time (n = 5 per week). (G) Intracardiac injection of BrdU stained prostate cancer was performed (n = 5). After 24 h injection, BrdU levels in DTCs were examined in the CSC vs. whole populations. *p < 0.05 (Student's t-test). (H) Prostate cancer was inoculated intratibially, and evaluated for CSCs after 24 h (n = 5). *p < 0.05 vs. in vitro cultured prostate cancer (Student's t-test).