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. 2016 May 10;7(27):41251–41264. doi: 10.18632/oncotarget.9275

Figure 3. Effect of NOTCH inhibition combined with TMZ and RT on 3D spheroid growth in vitro.

Figure 3

(A) Schematic of the 3D spheroid assay treatment schedules. (B–E) Individual spheroid growth in U87 cells was imaged 3 ×/week and the volume was calculated after indicated treatments till time to reach 20× starting volume. Spheroid growth demonstrates delays upon different treatment combinations compared with DMSO as vehicle control. Error bars indicates SEM. Asterisk indicates significance (*p < 0.05, **p < 0.01 and ***p < 0.001, ns: not significant).