Figure 7. Andrographolide associated reductions in viability of are less pronounced in noncancer cells.

A. Three dimensional primary cultures of mouse intestinal epithelial cells organoids were expanded and treated with Andrographolide IC₅₀ for 24 and 48 h and then stained with DAPI to evaluate nuclear morphology. B. Primary cultures of mouse bone marrow macrophages and human fibroblasts were treated with Andrographolide at the indicated dose range and compared to Andrographolide treated T84 cells for cell viability using the MTT assay. The data are expressed as the percentage of viable cells relative to untreated control cells. Data shown are from three independent experiments. (P < 0.05)