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. 2016 May 13;7(27):41662–41676. doi: 10.18632/oncotarget.9340

Figure 5. Modulation of TRAIL receptors in human monocytes by natural compounds.

Figure 5

A. Up-regulation of TRAIL-R expression upon treatment with Quercitin, Apigenin, Palmitate and Trabectedin for 24 hrs; results are shown as fold increase relative to untreated monocytes (mean±SE of 5 experiments). Indole-3-carbinole (I3C) has no effect on TRAIL-R modulation. B. Quercitin, Apigenin, Palmitate and Trabectedin induce cell death after 12hrs treatment; results are shown as % of dead cells (mean ± SE of 5 experiments). C. Immunofluorescence analysis of TRAIL-R2 (light blue) and lipid rafts (red) in treated monocytes. Quercitin and Trabectedin induce TRAIL-R2 co-localization into lipid rafts. Statistical analysis: *P < 0.05, ** P < 0.01, *** P < 0.001 (Student's t test).