Table 3. Characteristics of non-small cell lung cancer patients with MET exon 14 skipping.
Cases | Sex | Age | Smoking | P. | T. | Subtype | Stage | MET IHC | EGFR CN | HER2 CN | TTF1 |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 67 | Never | A | 3.5 | Acinar | IB | ++ | > 8 | > 6 | – |
2 | F | 77 | Never | A | 2 | Lepidic+Acinar | IB | + | > 4 | 2 | + |
3 | M | 66 | Smoker | A | 4 | Papillary | IIA | ++ | > 4 | 2 | + |
4 | F | 74 | Never | A | 2.3 | Lepidic | IA | ++ | > 6 | 2 | + |
5 | F | 54 | Never | A | 2 | Acinar+Papillary | IB | ++ | > 10 | 2 | – |
6 | M | 60 | Smoker | A | 4.5 | Solid | IB | ++ | > 7 | 2 | + |
7 | F | 75 | Never | A | 2.5 | Solid | IB | +++ | > 5 | 2 | + |
8 | F | 60 | Never | A | 4 | Acinar+Lepidic | IIB | + | > 8 | 2 | + |
9 | F | 62 | Never | A | 3 | Acinar+Solid | IA | ++ | > 5 | 2 | + |
10 | F | 49 | Never | A | 1 | AAH | 0 | – | 2 | 2 | + |
11 | F | 60 | Never | A | 2.8 | Lepidic | IA | + | 2 | 4 | + |
12 | F | 75 | Never | A | 2.5 | IMA+Acinar | IA | + | > 5 | 2 | – |
13 | M | 76 | Never | A | 0.5 | Acinar | IA | ++ | > 5 | > 5 | + |
14 | M | 76 | Smoker | A | 2.8 | Lepidic+Acinar | IA | – | > 5 | 3 | + |
15 | M | 67 | Never | A | 1.5 | AIS | 0 | – | 2 | 2 | + |
16 | F | 57 | Never | A | 0.8 | AIS | 0 | + | 2 | 2 | + |
17 | F | 73 | Never | A | 4 | Papillary | IIA | + | 2 | 2 | + |
18 | F | 47 | Never | A | 0.9 | AIS | 0 | – | 2 | 2 | + |
19 | F | 63 | Never | A | 2 | Papillary+Micropapillary | IIA | + | > 7 | 2 | + |
20 | M | 68 | Smoker | A | 3.2 | Solid | IIA | ++ | > 8 | > 3 | + |
21 | M | 68 | Never | A | 3.5 | Acinar+Solid | IIIA | +++ | > 5 | 3 | + |
22 | M | 65 | Smoker | AS | 10 | N.A. | IIB | + | > 4 | 2 | + |
23 | F | 77 | Never | AS | 1.5 | N.A. | IA | + | > 5 | > 4 | + |
Abbreviations: F, female, M, male; P, pathology; T. tumor size (cm); AAH, atypical adenomatous hyperplasia; AIS, adenocarcinoma in situ; IHC, MET immunohistochemistry; EGFR CN, EGFR gene copy by EGFR-FISH analysis; HER2 CN, HER2 gene copy by HER2-FISH analysis; N.A., not available; AAH, Atypical adenomatous hyperplasia; AIS, adenocarcinoma in situ (AIS).