Table 2. Univariate and multivariate analyses of clinicopathological and TACC3 expression for overall and diseasefree survival in overall cohort (n = 161) by Cox regression analyses.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Overall survival
Age (< 53 vs. ≥ 53 years)	0.673 (0.392-1.155)	0.151
Gender (female vs. male)	0.814 (0.475-1.395)	0.454
Clinical stage (I-II vs. III vs. IV)	2.351 (1.745-3.166)	0.000	0.933 (0.397-2.194)	0.873
T clasffication (I-II vs. III vs. IV)	1.790 (1.274-2.514)	0.001	1.469 (1.050-2.054)	0.025
N clasffication (N0 vs. N+)	5.001 (2.500-10.003)	0.000	3.544 (0.758-16.566)	0.108
M clasffication (yes vs. no)	5.380 (3.020-9.584)	0.000	3.893 (1.177-12.874)	0.026
Tumor differentiation (I vs. II vs. III)	1.436 (0.571-3.611)	0.442
Histological type (no vs. yes)	1.032 (0.410-2.594)	0.947
Location (colon vs. rectal)	1.386 (0.808-2.379)	0.236
TACC3 expression (low vs. high)	1.994 (1.153-3.448)	0.012	1.095 (1.095-3.314)	0.023
Disease-free survival
Age (< 53 vs. ≥ 53 years)	0.615 (0.349-1.084)	0.093
Gender (female vs. male)	0.884 (0.502-1.558)	0.670
Clinical stage (I-II vs. III vs. IV)	3.077 (2.141-4.421)	0.000	1.512 (0.792-2.887)	0.210
T clasffication (I-II vs. III vs. IV)	1.490 (1.094-2.028)	0.011	1.274 (0.933-1.741)	0.127
N clasffication (N0 vs. N+)	3.331 (1.725-6.429)	0.000	1.168 (0.461-2.956)	0.744
M clasffication (yes vs. no)	10.35(5.766-18.575)	0.000	4.319 (1.395-13.374)	0.011
Tumor differentiation (I vs. II vs. III)	1.178 (0.430-3.230)	0.750
Histological type (no vs. yes)	0.639 (0.199-2.057)	0.453
Location (colon vs. rectal)	1.665 (0.944-2.938)	0.078
TACC3 expression (low vs. high)	2.301 (1.281-4.131)	0.004	2.045 (1.125-3.719)	0.019

Abbreviations: HR, hazard ratio; CI, confidence interval.