Figure 1. IFN-γ receptor deficiency enhanced intestinal tumorigenesis in Apc^Min/+ mice.

(A) Decreased survival of Ifngr1^−/−Apc^Min/+ mice (n = 14) when compared to Ifngr1^+/+Apc^Min/+ mice (n = 10). (*P < 0.05, **P < 0.01, ***P < 0.005, Mantel-Cox test.) (B) Concentrations of hemoglobin in Ifngr1^+/+Apc^Min/+ mice (n = 4) and Ifngr1^−/−Apc^Min/+ mice (n = 7), measured when the mice were 18 weeks old.(*P < 0.05, **P < 0.01, ***P < 0.005, Unpaired t test.) (C, D) Scoring of macroadenomas (≥ 0.5 mm in diameter) in small intestines and colons of Apc^Min/+ mice. (E) Size distribution of macroadenomas in small intestines. Tumors were scored under a stereoscopic microscopy in age matched Ifngr1^+/+Apc^Min/+ mice (n = 12) and Ifngr1^−/−Apc^Min/+ mice (n = 12).(*P < 0.05, **P < 0.01, ***P < 0.005, Unpaired t test.).