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. 2016 Jun 7;7(27):42172–42182. doi: 10.18632/oncotarget.9902

Figure 3. MiR-21 was crucial for primary lung cancer outgrowth.

Figure 3

(A) Freshly isolated human lung cancer cells from different tissues (n = 3) were transfected with miR-21 expression vector or the control for 24 h, and detected for their miR-21 expressions. (B) Freshly isolated human lung cancer cells from different tissues (n = 3) were transfected with miR-21 expression vector or control, and assayed for their outgrowth at the indicated time. (C) Freshly isolated human lung cancer cells from different tissues (n = 3) were transfected with miR-21 shRNA or the control and assayed for their outgrowth. (D, E) Freshly isolated human lung cancer cells from different tissues (n = 6) were transfected with miR-21 expression vector, miR-21 shRNA or the controls and injected into nude mice. Tumor volumes (mean ± SD) at the indicated time were determined from 6 mice per group.