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. 2016 May 31;7(27):42183–42194. doi: 10.18632/oncotarget.9741

Figure 3. GAPLINC promoted CRC cell proliferation and invasion in vitro.

Figure 3

A. Relative expression level of GAPLINC in CRC cell lines. B. GAPLINC mRNA levels of empty vector, GAPLINC-siRNA1, GAPLINC-siRNA2, and GAPLINC-pcDNA3.1 by qRT-PCR in HCT116 and DLD-1 cells. C, D. CCK-8 viability and colony-forming growth assays showed that HCT116 and DLD-1 cells transfected with siRNA1 inhibited the cell proliferation of CRC cells and increased the proliferation with GAPLINC-pcDNA3.1. E. Transwell assay showed that the knockdown of GAPLINC significantly suppressed cell invasion ability and upregulated GAPLINC-enhanced invasion. Data represent mean ± standard deviation from three independent experiments. *P < 0.05, **P < 0.01.