Skip to main content
. 2016 May 31;7(27):42195–42207. doi: 10.18632/oncotarget.9743

Figure 4. Accumulation and anti-tumor effects of neutrophils in tumor tissue.

Figure 4

A. To examine neutrophil accumulation in B16-F10 melanoma-bearing mice treated with PBS, poly I:C, HVJ-E or HVJ-E+poly I:C (H+P), the tumors were isolated after 3 injections with each reagent, and the ratio of CD11b+Ly6G+ cells to CD45+ cells in tumor tissues was analyzed using flow cytometry (n=4). B. To assess N1 neutrophil infiltration, the CD11b+Ly6G+FAS+ cell population was analyzed in tumor tissues (n=5). C. The effects of neutrophils on tumor suppression with HVJ-E+poly I:C were evaluated after the intratumoral administration of an anti-neutrophil antibody (50 μg/mouse) 24 hours before the combination treatment (n=6). ** Indicates p<0.01, and * indicates p<0.05.