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. 2016 Jun 11;7(27):42261–42273. doi: 10.18632/oncotarget.9950

Figure 7. miR-192-5p and miR-500a-3p involved in LY6K and ERα are related to tamoxifen resistance in breast cancer patients.

Figure 7

(A) The relative LY6K expression depending on ER status in kao-breast cancer from oncomine™. (B) miR-192-5p expression in non-recurrence and recurrence primary breast tumors after tamoxifen treatment. The data were obtained from GSE 46823 (C) miR-500a-3p expression showed non-significant differences between non-recurrence and recurrence primary breast tumors after tamoxifen treatment. The data were obtained from GSE 46823. (D) Low expression of miR-500a-3p was correlated with poor survival outcomes in breast cancer patients received tamoxifen mono-therapy. (E) Hypothetical schematic pathway image. The mechanism for miR-192-5p and miR-500a-3p effects on tamoxifen susceptibility through the regulation of target genes in breast cancer. *P < 0.05; ns, non-significant.