Figure 3a &b. P-gp over expressing resistant KB cells were incubated with 1. Control, 2. Positive Control (Cylosporine A), 3. GLU alone, iv. PTX alone and v. GLU-PTX.

The level of fluorescence intensity of Rh123 was analyzed by flow cytometry. Data are mean ± S.D from three independent experiments. *P ≤ 0.05 significantly different from control. c. Schematic representation of mechanism involved in MDR transport function from cancer cells treated with GLU. In MDR cells, overexpression of MDR transporter proteins increases expulsion of Rh123 from the cell membrane before enzymatic hydrolysis of its esters, thus reducing accumulation of intracellular Rh123. However, GLU inhibit the transport function thereby enhances the accumulation of Rh123 inside the cells.