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. 2016 Jun 7;7(27):42408–42421. doi: 10.18632/oncotarget.9878

Figure 4. In vivo anticancer efficacy of CRLX101 against brain tumors.

Figure 4

Brain tissues were removed and sectioned for H&E staining and IHC analyses of EGFR and GFAP A. Time line of CRLX101 and camptothecin (CPT) administration in nude mice bearing intracranial U87 MG gliomas B. A Kaplan-Meier survival curve was analyzed by a log-rank test C. Expression levels of topoisomerase I (Topo-I) in tumor sections were analyzed by IHC, and representative images are shown D. A TUNEL assay was performed on sections from each group of mice. Representative images are shown E. TUNEL-positive cells were quantified and are expressed as percent stained per field F. Each value represents the mean ± SE. *, p<0.05, compared with respective control. #, p<0.05, compared with CPT group. Scale, 100 μm.