. 2016 Dec 20;11(12):e0168794. doi: 10.1371/journal.pone.0168794

Table 1. Ceramide proportions in the GG classes of the retina and other ocular tissues, brain and plasma.

A. (36:1+38:1) ceramides

B. 34:1 ceramides

GG classes

Retina

Brain

RPE / Choroid

Ciliary Body

Optic nerve

Plasma

Retina

Brain

RPE / Choroid

Ciliary Body

Optic nerve

Plasma

GM3

0.05^d

0.04^d

0.19^b

0.17^b

0.08^c

0.37^a

0.61^b

0.71^a

0.26^c

0.17^d

0.14^e

GM2

0.03^b

N.D.

0.26^a

0.01^c

0.25^a

0.95^a

0.91^a

N.D.

0.41^b

0.81^a

0.32^b

GD3

0.06^c

0.02^e

0.20^b

0.23^b

0.05^d

0.39^a

0.54^b

0.84^a

0.24^cd

0.18^d

0.31^c

0.10^e

AcGD3

0.06^b

0^d

N.D.

0.32^a

0.03^c

N.D.

0.66^b

0.65^b

N.D.

0.12^c

0.85^a

N.D.

GD2

0.01^b

0.01^bc

N.D.

0.28^a

0^d

N.D.

0.96^a

0.95^a

N.D.

0.66^a

1.00^a

N.D.

GD1a

0.03^d

0.01^e

0.04^c

0.17^b

0^e

0.39^a

0.87^a

0.89^a

0.16^d

0.28^c

0.38^b

GD1b

0.01^bc

0.01^c

0.01^bc

0.20^a

0^d

0.04^b

0.90^a

0.92^a

0.86^a

0.70^b

0.69^b

0.84^a

AcGD1b

0^a

N.D.

0^a

N.D.

0.90^a

0.99^a

N.D.

1.00^a

N.D.

GT3

0.04^a

0^b

N.D.

0.34^b

0.98^a

N.D.

AcGT3

0.02^a

0^b

N.D.

0.38^b

1.00^a

N.D.

GT1b

0.02^b

0.01^bc

0.01^b

0.16^a

0^c

0.11^a

0.85^a

0.96^a

0.76^a

0.54^b

0.57^b

0.60^b

AcGT1b

0^b

0.26^a

0^b

N.D.

0.94^a

0.96^a

N.D.

0.32^b

0.86^a

N.D.

GQ1b

0^b

0.20^a

0^b

N.D.

0.85^a

0.93^a

1.00^a

0.69^a

0.74^a

N.D.

AcGQ1b

0^a

N.D.

0^a

N.D.

1.00^a

N.D.

0.93^b

N.D.

C. (40:1+42:2+42:1) ceramides

D. Ceramides with 1 unsaturation

GG classes

Retina

Brain

RPE / Choroid

Ciliary Body

Optic nerve

Plasma

Retina

Brain

RPE / Choroid

Ciliary Body

Optic nerve

Plasma

GM3

0.85^a

0.84^a

0.69^c

0.65^d

0.61^e

0.72^b

0.21^d

0.19^d

0.43^b

0.46^b

0.60^a

0.27^c

GM2

0.99^a

0.96^a

N.D.

0.83^c

0.89^b

0.71^d

0.01^d

0.02^c

N.D.

0.30^a

0.15^b

0.27^a

GD3

0.87^a

0.91^a

0.70^b

0.71^b

0.70^b

0.67^b

0.32^c

0.10^d

0.46^a,b

0.41^b

0.53^a

0.30^c

AcGD3

0.93^b

0.70^d

N.D.

0.76^c

0.99^a

N.D.

0.22^b

0.05^d

N.D.

0.48^a

0.10^c

N.D.

GD2

0.99^a

0.98^a

N.D.

0.97^a

1.00^a

N.D.

0.02^c

0.03^b

N.D.

0.06^a

0^d

N.D.

GD1a

0.93^a

0.65^d

0.69^c

0.68^c

0.84^b

0.03^f

0.05^e

0.75^a

0.42^b

0.33^c

0.08^d

GD1b

0.98^a

0.97^a

0.96^a

0.95^a

0.94^a

0.95^a

0.07^b

0.05^b

0.12^b

0.08^b

0.27^a

0.10^b

AcGD1b

0.93^a

0.99^a

N.D.

1.00^a

N.D.

0.03^a

0^b

N.D.

0^b

N.D.

GT3

0.81^b

0.98^a

N.D.

0.54^a

0^b

N.D.

AcGT3

0.80^b

1.00^a

N.D.

0.52^a

0^b

N.D.

GT1b

0.96^ab

0.98^a

0.93^ab

0.85^c

0.90^bc

0.85^c

0.11^b

0.01^c

0.21^a

0.25^a

0.35^a

0.24^a

AcGT1b

1.00^a

0.99^a

0^b

0.65^a

1.00^a

N.D.

0.06^ab

0.04^b

0^c

0.17^ab

0.14^a

N.D.

GQ1b

0.97^bc

0.97^c

1.00^a

0.98^b

0.97^bc

N.D.

0.13^b

0.04^d

0^e

0.10^c

0.26^a

N.D.

AcGQ1b

1.00^a

N.D.

1.00^a

N.D.

0^b

N.D.

0.07^a

N.D.

E. Ceramides with 2 unsaturations

F. Ceramides ≤ 34 carbons

GG classes

Retina

Brain

RPE/ Choroid

Ciliary Body

Optic nerve

Plasma

Retina

Brain

RPE/ Choroid

Ciliary Body

Optic nerve

Plasma

GM3

0.15^d

0.16^d

0.31^bc

0.35^ab

0.39^a

0.28^c

0.05^d

0.04^d

0.20^b

0.19^b

0.08^c

0.44^a

GM2

0.01^e

0.04^d

N.D.

0.17^b

0.11^c

0.29^a

0.03^b

N.D.

0.26^a

0.01^c

0.27^a

GD3

0.13^b

0.09^c

0.30^a

0.29^a

0.30^a

0.33^a

0.06^c

0.02^e

0.21^b

0.25^b

0.05^d

0.48^a

AcGD3

0.07^b

0.30^a

N.D.

0.24^a

0.01^c

N.D.

0.06^b

0^d

N.D.

0.32^a

0.03^c

N.D.

GD2

0.01^b

0.02^a

N.D.

0.03^a

0^c

N.D.

0.01^b

0.01^bc

N.D.

0.28^a

0^c

N.D.

GD1a

0.07^c

0.35^a

0.31^a

0.32^a

0.16^b

0.03^d

0.01^e

0.04^c

0.18^b

0^e

0.46^a

GD1b

0.02^a

0.03^a

0.04^a

0.05^a

0.06^a

0.05^a

0.01^bc

0.01^c

0.01^bc

0.20^a

0^d

0.05^b

AcGD1b

0.01^a

N.D.

0^b

N.D.

0^a

N.D.

0^a

N.D.

GT3

0.19^a

0.02^b

N.D.

0.04^a

0^b

N.D.

AcGT3

0.19^a

0^b

N.D.

0.02^a

0^b

N.D.

GT1b

0.04^b

0.02^c

0.07^ab

0.15^a

0.10^a

0.15^a

0.02^b

0.01^bc

0.01^b

0.16^a

0^c

0.11^a

AcGT1b

0^b

0.01^a

0^b

0.10^a

0^b

N.D.

0^b

N.D.

0.26^a

0^b

N.D.

GQ1b

0.03^a

0^c

0.01^b

0.03^a

N.D.

0^b

0.20^a

0^b

N.D.

AcGQ1b

0^a

N.D.

0^a

N.D.

0^a

N.D.

0^a

N.D.

G. Ceramides ≥ 42 carbons

GG classes

Retina

Brain

RPE/ Choroid

Ciliary Body

Optic nerve

Plasma

GM3

0.10^e

0.17^d

0.37^b

0.56^a

0.21^c

GM2

0^c

0.01^c

N.D.

0.23^a

0.15^b

0.22^a

GD3

0.18^c

0.08^d

0.39^a

0.29^b

0.43^a

0.30^b

AcGD3

0^b

N.D.

0.32^a

0^b

N.D.

GD2

0^b

0.01^b

N.D.

0.04^a

0^b

N.D.

GD1a

0.01^e

0.65^a

0.37^b

0.23^c

0.07^d

GD1b

0.01^b

0.06^a

0.12^a

0.05^a

AcGD1b

0^a

N.D.

0^a

N.D.

GT3

0.31^a

0^b

N.D.

AcGT3

0.29^a

0^b

N.D.

GT1b

0.03^b

0.01^c

0.11^a

0.21^a

0.20^a

AcGT1b

0^b

0.14^a

0^b

N.D.

GQ1b

0.03^b

0^c

0.06^a

0.07^a

N.D.

AcGQ1b

0^a

N.D.

0^a

N.D.

Data are presented as proportions (mean of 4–7 independent samples). Seven variables were considered: (36:1+38:1) ceramides, 34:1 ceramides, (40:1+42:2+42:1) ceramides, ceramides with 1 unsaturation, ceramides with 2 unsaturations, ceramides with 34 carbons or less and ceramides with 42 carbons or more. Letters refer to results of the Student Newman Keuls multiple comparisons of tissues. For each variable, within a GG class, the letter "a" is attributed to the highest proportions among the 6 tissues considered. Different letters indicate significant differences in the proportions between tissues (p<0.05). N.D.: Non-detected GG class.