Table 1. Up- or down-regulated proteins in bovine RPE cells under oxidative stress.

Up-down/Spot#	Protein identified	Predicted Function	Scorea	Coverage	Mass	pI	Human diseaseb
Up N1	Neurofilament triplet H protein	Cytoskeletal protein	208	30	112168	8.02	ALS
Up N2	Neurofilament triplet M protein		115	12	103074	4.91	Alzheimer's
Up N3	peripherin		146	21	63566	5.42	RP
Up N4	Neurofilament triplet L protein		329	45	62665	4.59	ALS
Up N14	Glial fibrillary acidic protein		237	71	49538	5.36	Alexander D
Up N16	14-3-3 zeta	Cell signaling	71	45	28272	4.75	schizophrenia
Up N5, 6	Calreticulin	Chaperon	212/104	51/29	46524	4.31	Alzheimer's
Up N7	TNFR-associated protein 1	Inflammation	101	32	79331	6.66	Autoimmune disease
Up N13	Dimethylarginine Dimethylamino hydrolase 1	NO synthesis	104	33	30573	5.71	Alzheimer's
Up N15	Annexin V	apoptosis	194	56	35992	4.86	aging
Up N8	Pyruvate kinase M1	Metabolic enzyme	167	52	58994	7.96	cancer
Up N11, 12	Pyruvate dehydrogenase E1		206	40	43835	8.17	-
Up N9	UV excision repair protein RAD23	DNA repair	68	21	33511	4.7	-
Up N10	(2-5) oligo (A) synthetase	RNA synthesis	67	33	58071	9.23	-
Up N17	HNRPM protein		72	25	58716	8.94	-
Up N25	Glutathione S-transferase Pi	Redox enzyme	71	28	23826	6.89	Lung/prostate cancer
Up N26	RPE65	Visual cycle	161	33	61590	6	LCA, RP
Down N18	Tripeptidyl-peptidase 1	Protein degradation	92	22	61770	6.28	Lipofuscinosis (NCL)
Down N19	DNA replication factor	Cell cycle	73	33	73163	9.76	-
Down N20	Endothelial differentiation-related factor	Cell differentiation	72	57	16359	9.95	-
Down N21	Prohibitin	Cell proliferation	100	63	29843	5.57	aging
Down N22	Retinol binding protein (RBP)	Retinoid metabolism	82	69	15473	5.89	recess RPE degeneration
Down N23	Cytochrome c oxidase VIc	Cell respiratory	55	82	8473	10.28	-
Down N24	Platelet-derived growth factor R like	Cell signaling	72	27	57143	9.36	-

^aProbability-based MASCOT MOWSE score is -10*Log(P), where P is the probability that the observed match is a random event. Protein scores greater than 55 are significant (p<0.05).

^bRelated diseases based on Retnet database (http://www.sph.uth.tmc.edu/retnet/disease.htm) and IHOP (information hyperlinked over proteins, http://www.ihop-net.org/UniPub/iHOP/).