. Author manuscript; available in PMC: 2016 Dec 20.

Published in final edited form as: J Proteomics. 2010 Nov 11;74(2):254–261. doi: 10.1016/j.jprot.2010.11.004

Table 2. Up-regulated proteins in human RPE D407 cells under oxidative stress.

Spot number	Protein identified	Predicted function^a	MOWSE Score	% Coverage	Mass	pI	Human disease
D1	EF2	Protein synthesis	214	39	96246	6.41	Alzheimer's
D9	Elongation factor Tu	Protein synthesis	168	61	49852	7.26	-

D2	Hsp 90 alpha	Chaperone	61	20	85006	4.94	lens apoptosis
D17	Hsp beta 1	Chaperone	94	42	22826	5.98	lens apoptosis

D3	Ribonucleoside-diphosphate reductase	DNA synthesis	78	27	90925	6.76	Lung cancer cell line
D7	Inosine-5′-monophosphate dehydrogenase 2 (IMPDH2)	DNA synthesis	122	49	56226	6.44	IMPDH1 with RP

D4	DDX3X	RNA transcription	61	28	73597	6.73	Breast cancer

D5	Plasminogen activator inhibitor 1 (SERBP1)	RNA binding	66	25	44995	8.66	Ovarian cancer

D6	ATP dependent RNA helicase DDX1	RNA metabolism	112	31	83349	6.81	Neuroblastoma

D8	Lamin-A/C ^(d)	Nuclear envelope	148	40	74380	6.57	Lipodystrophy, cardiomyopathy, aging

D10	BUB3	Cell cycle	77	36	37587	6.36	Bladder/gastric/breast cancer

D11	RAN	GTP binding protein	72	44	24579	7.01	Kennedy's disease
D13	Guanine binding protein B2L1	GTP binding protein	88	46	35511	7.6	-

D12	Voltage-dependent anion-selective channel protein VDAC2	Channel protein	84	48	32060	7.49	Alzheimer's, Down syndrome

D14	Peroxiredoxin-1	Antioxidant enzyme	191	73	22324	8.27	Parkinson's
D16	Peroxiredoxin-1		191	73	22324	8.27	Parkinson's
D19	Thioredoxin-dependent peroxide reductase (PRDX3)		56	21	28017	7.67	-
D20	Peroxiredoxin 2		74	50	15243	5.82	Parkinson's

D18	Phosphomevalonate kinase	Metabolic enzyme	149	66	22152	5.56	-