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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Nat Rev Rheumatol. 2016 Nov 10;13(1):41–51. doi: 10.1038/nrrheum.2016.178

Figure 2. Adenosine receptors.

Figure 2

Adenosine receptors are all G protein-coupled receptors whose signal transduction is mediated by activation of intracellular G proteins. ADORA1 has the highest affinity for adenosine and is activated by high picomolar to low nanomolar adenosine concentrations; ADORA2A is activated by concentrations of adenosine in the mid-nanomolar range. By contrast, ADORA2B and ADORA3 are activated by adenosine concentrations in the micromolar range.