Table 2.
Fixed‐effect coefficients from linear mixed model regression for association between 10‐year drinking typologies and inflammatory marker trajectories during the following 12 years
| Loge C‐reactive protein (mg L−1) | Loge interleukin‐6 (ng mL−1) | Loge interleukin‐1 receptor antagonist (ng mL−1) | ||||
|---|---|---|---|---|---|---|
| Age and sex adjusted | Multivariable adjusted | Age and sex adjusted | Multivariableaadjusted | Age and sex adjusted | Multivariable adjusted | |
| Intercept | −0.280*** (−0.316, −0.244) | −0.679*** (−0.725, −0.632) | 0.329*** (0.310, 0.348) | 0.147*** (0.122, 0.173) | 5.554*** (5.534, 5.573) | 5.408*** (5.381, 5.435) |
| Stable nondrinker | 0.231*** (0.142, 0.320) | 0.146** (0.057, 0.236) | 0.174*** (0.124, 0.224) | 0.099*** (0.048, 0.151) | 0.072* (0.010, 0.134) | 0.065* (0.007, 0.123) |
| Stable moderate drinker | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) |
| Stable heavy drinker | 0.251*** (0.160, 0.343) | 0.156*** (0.067, 0.244) | 0.142*** (0.094, 0.191) | 0.109*** (0.060, 0.157) | 0.033 (−0.016, 0.083) | −0.005 (−0.053, 0.044) |
| Nonstable drinker | 0.133*** (0.074, 0.192) | 0.075* (0.018, 0.132) | 0.064*** (0.033, 0.095) | 0.039* (0.008, 0.070) | 0.011 (−0.022, 0.044) | −0.009 (−0.040, 0.023) |
| Former drinker | 0.121** (0.035, 0.207) | 0.071 (−0.011, 0.154) | 0.118*** (0.073, 0.164) | 0.089*** (0.044, 0.135) | 0.045 (−0.007, 0.097) | 0.041 (−0.009, 0.092) |
| Time (per year) | 0.033*** (0.030, 0.037) | 0.027*** (0.024, 0.031) | 0.020*** (0.018, 0.022) | 0.019*** (0.017, 0.021) | 0.034*** (0.032, 0.036) | 0.031*** (0.028, 0.033) |
| Stable nondrinker × time | 0.004 (−0.005, 0.012) | 0.004 (−0.005, 0.013) | −0.002 (−0.007, 0.004) | −0.000 (−0.006, 0.005) | 0.002 (−0.005, 0.009) | 0.004 (−0.002, 0.011) |
| Stable moderate drinker × time | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) | 0.000 (ref) |
| Stable heavy drinker × time | −0.005 (−0.013, 0.004) | −0.005 (−0.014, 0.004) | 0.010*** (0.005, 0.016) | 0.009** (0.003, 0.014) | 0.004 (−0.002, 0.010) | 0.005 (−0.001, 0.011) |
| Nonstable drinker × time | −0.003 (−0.008, 0.003) | −0.003 (−0.008, 0.003) | −0.004* (−0.007, −0.000) | −0.004* (−0.007, −0.000) | 0.000 (−0.004, 0.004) | 0.001 (−0.003, 0.005) |
| Former drinker × time | 0.003 (−0.006, 0.011) | 0.003 (−0.006, 0.011) | −0.004 (−0.009, 0.001) | −0.004 (−0.009, 0.001) | 0.005 (−0.000, 0.011) | 0.005 (−0.001, 0.010) |
| N (no. of observations) | 8128 (19 097) | 7814 (18 097) | 8183 (19 182) | 7868 (18 179) | 3468 (9564) | 3443 (9244) |
***P < 0.001; **P < 0.01; *P < 0.05.
a
Multivariable adjustment for age, sex, ethnicity, prevalent coronary heart disease or type 2 diabetes at phase 3, socio‐economic position, smoking status, physical activity, diet and body mass index.