Table 1.
All possible reportable disease risk values*
| Disease | Genetic Variant RR | Family History RR** | BMI RR | Smoking RR | Diabetes RR | Number of risk variables |
|---|---|---|---|---|---|---|
| AMD | 2.4, 6.0 | 4.0 | NA | 1.4, 2.0 | NA | 5 |
| CAD | 1.3, 1.7 | 1.2, 1.4 | NA | 2.1*** | 1.7 | 6 |
| DM1 | 0.08, 0.3 | 2.3; 6.6 | NA | NA | NA | 4 |
| DM2 | 1.2, 1.3 | 1.3, 1.9 | 2.3, 5.9 | NA | NA | 6 |
| HH | 27.0**** | NA | NA | NA | NA | 1 |
| LUP | 1.4, 2.0 | 4.1, 11.3 | NA | 1.5 | NA | 5 |
| MEL | 1.7, 3.0 | 2.2 | NA | NA | NA | 3 |
| PRO | 1.5 | 1.9 | NA | NA | NA | 2 |
| Total | 14 | 11 | 2 | 4 | 1 | 32 |
RR: Relative Risk
NA: not applicable risk factor
*
Values for Caucasian population represented
**
Positive family history defined as follows 5:
- AMD: one or more first-degree relatives with age-related macular degeneration
- CAD: one or both parents diagnosed with coronary artery disease
- DM2: one or both parents with type 2 diabetes
- LUP: one or two or more first-degree relatives with a history of any of 11 autoimmune diseases
- MEL: one or more first-degree relatives with melanoma
- PRO: biological father or any brothers diagnosed with prostate cancer
***
RR varies by gender and race
****
RR only provided to males. Male heterozygotes and homozygote wild type received an RR of 1.0; females got absolute risk: homozygotes received 16% lifetime risk, heterozygotes and wild type homozygotes received a lifetime risk of 1%.
AMD: Age Related Macular Degeneration
CAD: Coronary Artery Disease
DM1: Type 1 Diabetes
DM2: Type 2 Diabetes
HH: Hemochromatosis
LUP: Systemic Lupus Erythematosus
MEL: Melanoma
PRO: Prostate cancer