Table 2: Key eligibility criteria for reimbursement of simeprevir with peginterferon plus ribavirin for treatment of hepatitis C virus infection, by jurisdiction.
Jurisdiction | Restriction | ||||
---|---|---|---|---|---|
Minimum fibrosis stage required | Substance use | HIV coinfection | Prescriber | Decompensated cirrhosis | |
Province/territory | |||||
British Columbia | F2 | None listed | None listed | General practitioner | None listed |
Alberta | F2 | None listed | None listed | None listed | Ineligible |
Saskatchewan | F2 | None listed | None listed | General practitioner | None listed |
Manitoba | F2 | None listed | Eligible | Specialist | Ineligible |
Ontario | F2 | None listed | Eligible | General practitioner | Ineligible |
Quebec | None listed* | None listed | Ineligible† | None listed | None listed |
New Brunswick | F2 | None listed | None listed | None listed | Ineligible |
Nova Scotia | F2 | None listed | None listed | Specialist‡ | Ineligible |
Prince Edward Island | NA | NA | NA | NA | NA |
Newfoundland and Labrador | F2 | None listed | None listed | None listed | Ineligible |
Yukon | F2 | None listed | None listed | Specialist | Ineligible |
Northwest Territories | F2 | None listed | None listed | Specialist‡ | None listed |
Nunavut | F2 | None listed | None listed | Specialist‡ | None listed |
Federal | |||||
Non-Insured Health Benefits Program | F2 | None listed | None listed | Specialist‡ | None listed |
Correctional Service Canada | F2§ | None listed¶ | None listed | None listed | None listed |
Note: NA = not available.
*However, coauthors indicated that in practice there were no fibrosis stage restrictions.
†However, exceptions could be granted via the "patient d'exception" (exception patient) measure.
‡None listed in criteria; however, a specialist prescription was required for peginterferon-based treatments.
§Treatment prioritized to patients with stage F3 or F4 fibrosis; treatment for those with stage F0, F1 or F2 fibrosis was reviewed on a case-by-case basis.
¶Directly observed therapy required.