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The subgroup of TspanC8 tetraspanins. The TspanC8 tetraspanins are an evolutionary conserved subgroup of tetraspanins, including Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33. TspanC8 tetraspanins interact with the APP α-secretase ADAM10 and regulate its maturation, surface expression and substrate cleavage. Alignment of the human TspanC8 amino acid sequences was performed with ClustalOmega and is presented as dendrogram.
