Table 3.
Association of SOX9 gene polymorphisms with ONFH subgroups.
| dbSNP |
Subgroup | Genotype∗ | MAF | Allele (2 versus 1) | Codominant (11 versus 12 versus 22)∗ | Dominant (12 + 22 versus 11) | Recessive (22 versus 11 + 12) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11 | 12 | 22 | OR (95% CI) | P # | OR (95% CI) | P # | OR (95% CI) | P # | OR (95% CI) | P # | |||
| rs1042667 (A>C) | AA | AC | CC | ||||||||||
| Ster▲ | 9 | 25 | 11 | 0.478 | 0.946 | 0.814 | 1.059 | 0.812 | 1.125 | 0.568 | 0.967 | 0.863 | |
| (0.596~1.503) | (0.662~1.692) | (0.751~1.684) | (0.662~1.413) | ||||||||||
| Alc▲ | 19 | 35 | 14 | 0.463 | 1.198 | 0.370 | 0.861 | 0.694 | 0.964 | 0.903 | 0.894 | 0.535 | |
| (0.807~1.780) | (0.408~1.817) | (0.135~1.736) | (0.627~1.274) | ||||||||||
| Idio▲ | 11 | 30 | 26 | 0.462 | 0.656 | 0.040 | 1.843 | 0.073 | 0.404 | 0.772 | 1.376 | 0.047 | |
| (0.437~0.982) | (0.945~3.593) | (0.420~1.418) | (1.005~1.883) | ||||||||||
|
| |||||||||||||
| rs12601701 (G>A) | GG | GA | AA | ||||||||||
| Ster | 9 | 23 | 13 | 0.456 | 1.069 | 0.779 | 1.053 | 0.896 | 1.014 | 0.968 | 1.038 | 0.939 | |
| (0.672~1.699) | (0.481~2.283) | (0.519~1.980) | (0.721~1.496) | ||||||||||
| Alc | 16 | 30 | 22 | 0.456 | 1.067 | 0.747 | 1.637 | 0.161 | 0.658 | 0.168 | 1.212 | 0.242 | |
| (0.715~1.586) | (0.821~3.624) | (0.363~1.192) | (0.878~1.672) | ||||||||||
| Idio | 11 | 26 | 30 | 0.358 | 1.410 | 0.095 | 1.790 | 0.085 | 0.757 | 0.370 | 1.343 | 0.065 | |
| (0.941~2.113) | (0.922~3.476) | (0.412~1.391) | (0.982~1.835) | ||||||||||
▲Alc: Alcohol-induced; Ster: steroid- induced; Idio: idiopathic; ∗11: homozygotes for the major allele; 12: heterozygotes; and 22: homozygotes for the minor allele.
#Logistic regression analyses were used. Bold: P value < 0.05.